An Experiment With a Tadpole's Development

An early classic experiment by the Nobel Prize-winning embryologist Roger Sperry illustrates the principle perfectly. Sperry and a colleague took a tadpole and removed a tiny square of skin from the back. They removed another square, the same size, from the belly. They then regrafted the two squares, but each in the other's place: the belly skin was grafted on the back, and the back skin on the belly. When the tadpole grew up into a frog, the result was rather pretty, as experiments in embryo...